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KMID : 0383820050590020198
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Tuberculosis and Respiratory Diseases
2005 Volume.59 No. 2 p.198 ~ p.203
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A Case of Acromegaly Associated with Lung and Gastric Cancer
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Kim Jin-Soo
Kil Uk-Hyun
Song Do-Seon
Yang Hong-Jun
Lee Hyuck
Huh Min
Kim Jeong-Pyo
Kwon Soon-Seog
Kim Young-Kyoon
Kim Kwan-Hyoung
Moon Hwa-Sik
Song Jeong-Sup
Park Sung-Hak
Ahn Joong-Hyun
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Abstract
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Patients with acromegaly have high incidence of benign or malignant neoplasia than general population. Around fifteen percent of the deaths reported in acromegaly are attributable to malignancy of cancer. On the whole, mortality in acromegaly has been shown to be correlated with the degree of growth hormone (GH) control. Especially, the levels of insulin like growth factor-1 (IGF-1) may be higher in neoplasm, but there is no clear evidence to prove that tumor development is triggered by IGF-1 in acromegaly.
Henceforth, we report a case of acromegaly associated with lung and gastric cancer in a 58-year-old man, suggesting the possible carcinogenic role of IGF-1.
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KEYWORD
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Acromegaly, Lung cancer, Gastric cancer
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